An Efficient Cascade Synthesis of Ethyl 3-Amino-5-oxoisoxazolidine-4-carboxylate Derivatives
Runrun Li, Qiang Wei, Xin Wang, Zemei Ge, Runtao Li*
*State Key Laboratory of Nature and Biomimetic Drugs, School
of Pharmaceutical Sciences, Peking University, Beijing 100191, P. R. of China,
Email: lirt
bjmu.edu.cn
R. Li, Q. Wei, X. Wang, Z. Ge, R. Li, Synthesis, 2017, 49, 4341-4349.
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Abstract
An efficient cascade reaction of diethyl 2-(ethoxymethylene)malonate, different hydroxylamines and various amines provides ethyl 3-amino-5-oxoisoxazolidine-4-carboxylate derivatives, which are expected to be important in organic synthesis and medicinal chemistry.
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Key Words
isoxazolidines, 4-isoxazolines, cascade synthesis, amines, Michael addition
ID: J66-Y2017
