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Formyloxyacetoxyphenylmethane as an N-Formylating Reagent for Amines, Amino Acids, and Peptides

Robert S. L. Chapman, Ruth Lawrence, Jonathan M. J. Williams and Steven D. Bull*

*Department of Chemistry, University of Bath, Bath BA2 7AY, U.K., Email: s.d.bullbath.ac.uk

R. S. L. Chapman, R. Lawrence, J. M. J. Williams, S. D. Bull, Org. Lett., 2017, 19, 4908-4911.

DOI: 10.1021/acs.orglett.7b02383 (free Supporting Information)



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Abstract

Formyloxyacetoxyphenylmethane is a stable, water-tolerant, N-formylating reagent that can be used under mild, solvent-free conditions for the preparation of a range of N-formamides, N-formylanilines, N-formyl-α-amino acids, N-formylpeptides, and isocyanides.

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Key Words

amides


ID: J54-Y2017