Synthesis of Dihydropyrazoles via Ligand-Free Pd-Catalyzed Alkene Aminoarylation of Unsaturated Hydrazones with Diaryliodonium Salts

Meng-Nan Yang, Dong-Mei Yan, Quan-Qing Zhao, Jia-Rong Chen* and Wen-Jing Xiao*

*Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, China, Email: chenjiarongmail.ccnu.edu.cn, wxiaomail.ccnu.edu.cn

M.-N. Yang, D.-M. Yan, Q.-Q. Zhao, J.-R. Chen, W.-J. Xiao, Org. Lett., 2017, 19, 5208-5211.

DOI: 10.1021/acs.orglett.7b02480

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Abstract

A ligand-free, palladium-catalyzed aminoarylation of unactivated alkenes in β,γ-unsaturated hydrazones provides diversely substituted dihydropyrazoles in good yields via an efficient and simultaneous formation of C(sp³)-N and C(sp³)-C(sp²) bonds under mild conditions.

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Key Words

pyrazolines

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ID: J54-Y2017