Organic Chemistry Portal

Abstracts

Search:

Methylation of C(sp3)-H/C(sp2)-H Bonds with Methanol Catalyzed by Cobalt System

Zhenghui Liu, Zhenzhen Yang, Xiaoxiao Yu, Hongye Zhang, Bo Yu, Yanfei Zhao and Zhimin Liu*

*Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China, Email: liuzmiccas.ac.cn

Z. Liu, Z. Yang, X. Yu, H. Zhang, B. Yu, Y. Zhao, Z. Liu, Org. Lett., 2017, 19, 5228-5231.

DOI: 10.1021/acs.orglett.7b02462 (free Supporting Information)



see article for more reactions

Abstract

A highly efficient Co-based catalytic system, composed of a commercially available Co salt, a tetradentate phosphine ligand, and K2CO3 enables the methylation of C(sp3)-H/C(sp2)-H bonds using methanol as a methylating reagent. The catalytic system showed high catalytic activity for the methylation of C-H bonds in aryl alkyl ketones, aryl acetonitriles, and indoles, with wide substrate scope and good functional group tolerance.


see article for more examples

proposed mechanism



Key Words

ketones, indoles


ID: J54-Y2017