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Ruthenium Phosphine-Pyridone Catalyzed Cross-Coupling of Alcohols To form α-Alkylated Ketones

Apurba R. Sahoo , Gummidi Lalitha, V. Murugesh, Christian Bruneau, Gangavaram V. M. Sharma, Surisetti Suresh and Mathieu Achard*

*UMR 6226, Institut des Sciences Chimiques de Rennes, Université de Rennes 1, Campus de Beaulieu, 35042 Rennes Cedex, France, Email: mathieu.acharduniv-rennes1.fr

A. R. Sahoo, G. Lalitha, V. Murugesh, C. Bruneau, G. V. M. Sharma, S. Suresh, M. Achard, J. Org. Chem., 2017, 82, 10727-10731.

DOI: 10.1021/acs.joc.7b02042 (free Supporting Information)



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Abstract

An efficient dehydrogenative-dehydrative cross-coupling of primary and secondary alcohols catalyzed by a recently developed proton responsive ruthenium phosphine-pyridone complex enables a green route to functionalized ketones. Moreover, selective tandem double alkylation of isopropanol is achieved by sequential addition of different alcohols.

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proposed mechanism



Key Words

ketones


ID: J42-Y2017