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Sonogashira Reaction Using Arylsulfonium Salts as Cross-Coupling Partners

Ze-Yu Tian, Shi-Meng Wang, Su-Jiao Jia, Hai-Xia Song and Cheng-Pan Zhang*

*School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan 430070, China, Email:

Z.-Y. Tian, S.M. Wang, S.-J. Jia, H.-X. Song, C.-P. Zhang, Org. Lett., 2017, 19, 5454-5457.

DOI: 10.1021/acs.orglett.7b02764 (free Supporting Information)

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Triarylsulfonium, alkyl- and fluoroalkyl(diaryl)sulfonium, and aryl(dialkyl)sulfonium triflates are successfully used as cross-coupling participants in the Sonogashira reaction. Terminal alkynes reacted mildly with arylsulfonium salts at room temperature under Pd- and Cu-cocatalysis to give the corresponding arylalkynes in very good yield.

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Key Words

Sonogashira Coupling, Arylation

ID: J54-Y2017