Direct Palladium-Catalyzed Carbonylative Transformation of Allylic Alcohols and Related Derivatives
Fu-Peng Wu, Jin-Bao Peng*, Lu-Yang Fu, Xinxin Qi and Xiao-Feng Wu*
*Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018,
People's Republic of China; Universität Rostock, Albert-Einstein-Straße 29a,
Rostock 18059, Germany, Email: pengjb_05
zstu.edu.cn,
xiao-feng.wucatalysis.de
F.-P. Wu, J.-B. Peng, L.-Y. Fu, X. Qi, X.-F. Wu, Org. Lett., 2017, 19, 5474-5477.
DOI: 10.1021/acs.orglett.7b02801
see article for more reactions
Abstract
A direct, palladium-catalyzed, carbonylative transformation of allylic alcohols in the presence of formic acid as the CO source provides β,γ-unsaturated carboxylic acids with excellent linear and (E)-selectivity under mild conditions.
see article for more examples
proposed mechanism
Key Words
ID: J54-Y2017
