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Oxidative Synthesis of Benzimidazoles, Quinoxalines, and Benzoxazoles from Primary Amines by ortho-Quinone Catalysis

Ruipu Zhang, Yan Qin, Long Zhang and Sanzhong Luo*

*Key Laboratory for Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China, Email:

R. Zhang, Y. Qin, L. Zhang, S. Luo, Org. Lett., 2017, 19, 5629-5632.

DOI: 10.1021/acs.orglett.7b02786 (free Supporting Information)

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Bioinspired ortho-quinone catalysts have been applied to oxidative synthesis of benzimidazoles, quinoxalines and benzoxazoles from primary amines in high yields under mild conditions with oxygen as the terminal oxidant.

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Key Words

Benzimidazoles, Quinoxalines, Oxygen, Organocatalysis

ID: J54-Y2017