Convenient and Clean Synthesis of Isatins by Metal-Free Oxidation of Oxindoles
Wen-Ting Wei*, Wei-Wei Ying, Wen-Ming Zhu, Yi Wu, Yi-Ling Huang, Yi-Qi Cao, Yi-Ning Wang, Hongze Liang*
*School of Materials Science and Chemical Engineering, Ningbo
University, Ningbo 315211, P. R. of China,
Email: weiwentingnbu.edu.cn, lianghongze
nbu.edu.cn
W.-T. Wei, W.-W. Ying, W.-M. Zhu, Y. Wu, Y.-L. Huang, Y.-Q. Cao, Y.-N. Wang, H. Liang, Synlett, 2017, 28, 2307-2310.
DOI: 10.1055/s-0036-1590965
see article for more reactions
Abstract
A convenient oxidation of oxindoles with molecular oxygen in the presence of tert-butyl nitrite as an additive enables a mild and metal-free synthesis of isatins without the need for any catalyst or base.
see article for more examples
Synthesis of Indoline-2,3-diones by Radical Coupling of Indolin-2-ones with tert-Butyl Hydroperoxide
W.-W. Ying, W.-M. Zhu, H. Liang, W.-T. Wei, Synlett, 2018, 29, 215-218.
Key Words
oxindoles, isatins, tert-butyl nitrite, oxygen
ID: J60-Y2017