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Convenient and Clean Synthesis of Isatins by Metal-Free Oxidation of Oxindoles

Wen-Ting Wei*, Wei-Wei Ying, Wen-Ming Zhu, Yi Wu, Yi-Ling Huang, Yi-Qi Cao, Yi-Ning Wang, Hongze Liang*

*School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, P. R. of China, Email:,

W.-T. Wei, W.-W. Ying, W.-M. Zhu, Y. Wu, Y.-L. Huang, Y.-Q. Cao, Y.-N. Wang, H. Liang, Synlett, 2017, 28, 2307-2310.

DOI: 10.1055/s-0036-1590965

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A convenient oxidation of oxindoles with molecular oxygen in the presence of tert-butyl nitrite as an additive enables a mild and metal-free synthesis of isatins without the need for any catalyst or base.

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Synthesis of Indoline-2,3-diones by Radical Coupling of Indolin-2-ones with tert-Butyl Hydroperoxide

W.-W. Ying, W.-M. Zhu, H. Liang, W.-T. Wei, Synlett, 2018, 29, 215-218.

Key Words

oxindoles, isatins, tert-butyl nitrite, oxygen

ID: J60-Y2017