Oxidative Annulations Involving DMSO and Formamide: K₂S₂O₈ Mediated Syntheses of Quinolines and Pyrimidines

Santosh D. Jadhav and Anand Singh*

*Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur-208016, U.P. India, Email: anandsiitk.ac.in

S. D. Jadhav, A. Singh, Org. Lett., 2017, 19, 5673-5676.

DOI: 10.1021/acs.orglett.7b02838

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Abstract

An oxidative annulation involving anilines, aryl ketones, and DMSO as a methine (=CH−) equivalent promoted by K₂S₂O₈ provides 4-arylquinolines, whereas activation of acetophenone-formamide conjugates enables the synthesis of 4-arylpyrimidines.

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Key Words

Quinolines, Pyrimidines, Potassium Peroxydisulfate

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ID: J54-Y2017