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Synthesis of Indolizines via Palladium Catalyzed Annulation of Propargyl Carbonates and 2-(Pyridin-2-yl)acetonitrile Derivatives

Ting Wu, Min Chen and Yuzhu Yang*

*State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, 3491 Baijin Road, Guiyang 550014, P. R. China, Email: yangyuzhu15126.com

T. Wu, M. Chen, Y. Yang, J. Org. Chem., 2017, 82, 11304-11309.

DOI: 10.1021/acs.joc.7b02278 (free Supporting Information)


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Abstract

A Pd-catalyzed regioselective annulation of 2-(pyridine-2-yl) acetonitrile derivatives and propargyl carbonates provides a straightforward and efficient access to polysubstituted indolizines. The regioselectivity of the reaction highly depends on the choice of the phosphine ligand.

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Key Words

indolizines


ID: J42-Y2017