Nucleo-Palladation-Triggering Alkene Functionalization: A Route to γ-Lactones
Meifang Zheng, Pengquan Chen, Liangbin Huang, Wanqing Wu* and Huanfeng Jiang*
*School of Chemistry and Chemical Engineering, South China
University of Technology, Guangzhou 510640, P. R. China,
Email: jianghf
scut.edu.cn, cewuwqscut.edu.cn
M. Zheng, P. Chen, L. Huang, W. Wu, H. Jiang, Org. Lett., 2017, 19, 5756-5759.
DOI: 10.1021/acs.orglett.7b02688
see article for more reactions
Abstract
Palladium catalysis enables an unprecedented, highly effective synthesis of γ-lactones from homoallylic alcohols in one step. The protocol affords aryl, alkyl, and spiro γ-lactones directly from readily available homoallylic alcohols in good yields with excellent functional group tolerance and high chemoselectivity under mild conditions.
see article for more examples
proposed mechanism
Key Words
ID: J54-Y2017
