NHC-Copper-Catalyzed Tandem Hydrocupration and Allylation of Alkenyl Boronates
Won Jun Jang, Jung Tae Han, Jaesook Yun*
*Department of Chemistry and Institute of Basic Science, Sungkyunkwan University, Suwon 16419, Korea, Email: jaesookskku.edu
W. J. Jang, J. T. Han, J. Yun, Synthesis, 2017, 49, 4753-4758.
DOI: 10.1055/s-0036-1588811 (free Supporting Information)
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In the presence of IMes-Cu catalyst, a tandem hydrocupration/allylation of alkenyl boronates with allyl phosphate efficiently proceeds in the presence of a hydrosilane via in situ generated Β-α-copper intermediates. Mono- and disubstituted alkenyl boronates were effective in the reaction with terminal allyl phosphates, but trisubstituted substrates showed limited reactivity.
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J. T. Han, W. J. Jang, N. Kim, J. Yun, J. Am. Chem. Soc., 2016, 138, 15146-15149.