Electrocatalytic Radical Dichlorination of Alkenes with Nucleophilic Chlorine Sources

Niankai Fu, Gregory S. Sauer and Song Lin*

*Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States, Email: songlincornell.edu

N. Fu, G. S. Sauer, S. Lin, J. Am. Chem. Soc., 2017, 139, 15548-15553.

DOI: 10.1021/jacs.7b09388

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Abstract

A Mn-catalyzed electrochemical dichlorination of alkenes with MgCl₂ as the chlorine source provides an operationally simple, sustainable, and efficient access to a variety of vicinally dichlorinated compounds. In particular, alkenes with oxidatively labile functional groups, such as alcohols, aldehydes, sulfides, and amines, were transformed into the desired vicinal dichlorides with high chemoselectivity.

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Key Words

dichlorination, electrochemistry

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ID: J48-Y2017