Coupling Reaction of Cu-Based Carbene and Nitroso Radical: A Tandem Reaction To Construct Isoxazolines
Rongxiang Chen, Yanwei Zhao, Shangwen Fang, Wenhao Long, Hongmei Sun* and Xiaobing Wan*
*Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China, Email: wanxbsuda.edu.cn, sunhmsuda.edu.cn
R. Chen, Y. Zhao, S. Fang, W. Long, H. Sun, X. Wan, Org. Lett., 2017, 19, 5896-5899.
DOI: 10.1021/acs.orglett.7b02885 (free Supporting Information)
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An unprecedented cross-coupling reaction between copper carbenes and nitroso radicals provides various isoxazolines via construction of C-C, C-O, and C=N bonds in a one-pot process. The convenient method offers mild reaction conditions and wide substrate scope.
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