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Coupling Reaction of Cu-Based Carbene and Nitroso Radical: A Tandem Reaction To Construct Isoxazolines

Rongxiang Chen, Yanwei Zhao, Shangwen Fang, Wenhao Long, Hongmei Sun* and Xiaobing Wan*

*Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China, Email: wanxbsuda.edu.cn, sunhmsuda.edu.cn

R. Chen, Y. Zhao, S. Fang, W. Long, H. Sun, X. Wan, Org. Lett., 2017, 19, 5896-5899.

DOI: 10.1021/acs.orglett.7b02885 (free Supporting Information)



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Abstract

An unprecedented cross-coupling reaction between copper carbenes and nitroso radicals provides various isoxazolines via construction of C-C, C-O, and C=N bonds in a one-pot process. The convenient method offers mild reaction conditions and wide substrate scope.

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proposed mechanism



Key Words

2-isoxazolines, tert-butyl nitrite, multicomponent reactions


ID: J54-Y2017