Copper-Catalyzed C(sp2)-S Coupling Reactions for the Synthesis of Aryl Dithiocarbamates with Thiuram Disulfide Reagents
Zhi-Bing Dong*, Xing Liu and Carsten Bolm*
*Wuhan Institute of Technology, Wuhan 430205, China; RWTH Aachen University, Landoltweg 1, D-52056 Aachen, Germany, Email: dzb04982wit.edu.cn, carsten.bolmoc.rwth-aachen.de
Z.-B. Dong, X. Liu, C. Bolm, Org. Lett., 2017, 19, 5916-5919.
DOI: 10.1021/acs.orglett.7b02911
Abstract
A copper-catalyzed preparation of aryl dithiocarbamates from aryl iodides and inexpensive, environmentally benign tetraalkylthiuram disulfides offers mild reaction conditions, high yields, and broad substrate scope. This approach is synthetically attractive for the preparation of potentially biologically active compounds.
see article for more examples
proposed mechanism
Y.-X. Wu, K. Peng, J.-H. Li, Z.-B. Dong, Synthesis, 2020, 52, 3001-3006.
Q. Cao, H.-Y. Peng, Y. Cheng, Z.-B. Dong, Synthesis, 2018, 50, 1527-1534.
Key Words
ID: J54-Y2017