Highly Enantioselective Hydrosilylation of Ketones Catalyzed by a Chiral Oxazaborolidinium Ion
Byung Chul Kang, Sung Ho Shin, Jaesook Yun and Do Hyun Ryu*
*Department of Chemistry, Sungkyunkwan University, Suwon, 16419, Korea, Email: dhryuskku.edu
B. C. Kang, S. H. Shin, J. Yun, D. H. Ryu, Org. Lett., 2017, 19, 6316-6319.
DOI: 10.1021/acs.orglett.7b03076 (free Supporting Information)
see article for more reactions
A chiral oxazaborolidinium ion (COBI) catalyst enables a highly enantioselective hydrosilylation of ketones for the synthesis of various chiral secondary alcohols in good yields and excellent enantioselectivities.
see article for more examples
proposed transition state model