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Highly Enantioselective Hydrosilylation of Ketones Catalyzed by a Chiral Oxazaborolidinium Ion

Byung Chul Kang, Sung Ho Shin, Jaesook Yun and Do Hyun Ryu*

*Department of Chemistry, Sungkyunkwan University, Suwon, 16419, Korea, Email: dhryuskku.edu

B. C. Kang, S. H. Shin, J. Yun, D. H. Ryu, Org. Lett., 2017, 19, 6316-6319.

DOI: 10.1021/acs.orglett.7b03076 (free Supporting Information)


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Abstract

A chiral oxazaborolidinium ion (COBI) catalyst enables a highly enantioselective hydrosilylation of ketones for the synthesis of various chiral secondary alcohols in good yields and excellent enantioselectivities.

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proposed transition state model



Key Words

reduction of carbonyl compounds, silanes


ID: J54-Y2017