Catalytic Enantioselective Hetero-dimerization of Acrylates and 1,3-Dienes
Stanley M. Jing , Vagulejan Balasanthiran , Vinayak Pagar, Judith C. Gallucci and T. V. RajanBabu*
*Department of Chemistry and Biochemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, United States, Email: rajanbabu.1osu.edu
S. M. Jing, V. Balasanthiran, V. Pagar, J. C. Gallucci, T. V. Rajanbabu, J. Am. Chem. Soc., 2017, 139, 18034-18043.
DOI: 10.1021/jacs.7b10055 (free Supporting Information)
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A practical, highly enantioselective reaction of readily available 1,3-dienes and alkyl acrylates provides valuable, enantio-pure skipped 1,4-diene esters in the presence of commercially available cobalt salts and chiral ligands. This hetero-dimerization reaction tolerates various organic functional groups (e.g., aromatic substituents, halides, isolated mono- and di-substituted double bonds, esters, silyl ethers, and silyl enol ethers).
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