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Recyclable [Ce(l-Pro)2]2 (Oxa) used as Heterogeneous Catalyst: One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones in Ethanol

Ramesh Katla*, Rakhi Chowrasia, Caren D. G. da Silva, Aline R. de Oliveira, Beatriz F. dos Santos, Nelson L. C. Domingues*

*Federal University of Grande Dourados-UFGD, Dourados/Itah˙m rod. km 12 s/n, Zip Code 79804-970, Dourados, MS, Brazil, Email:,

R. Katla, R. Chowrasia, C. D.G. da Silva, A. R. de Oliveira, B. F. dos Santos, N. L. C. Domingues, Synthesis, 2017, 49, 5143-5148.

DOI: 10.1055/s-0036-1590886

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The use of [Ce(l-Pro)2]2 (Oxa) as recyclable heterogeneous catalyst enables the preparation of 2-aryl-2,3-dihydroquinazolin-4(1H)-one derivatives from anthranilamide and several aldehydes under mild conditions in ethanol at 50-55░C. The catalyst can be recycled and reused three times without significant loss of catalytic activity.

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Key Words

2,3-dihydroquinazolin-4(1H)-ones, heterogeneous catalysis, anthranilamide, benzaldehydes, hybrid catalysts

ID: J66-Y2017