Photoinduced, Copper-Promoted Regio- and Stereoselective Decarboxylative Alkylation of α,β-Unsaturated Acids with Alkyl Iodides
Chao Wang, Yingjie Lei, Mengzhun Guo, Qinyu Shang, Hong Liu, Zhaoqing Xu* and Rui Wang*
*The Institute of Pharmacology, School of Basic Medical
Science, Lanzhou University, 199 West Donggang Road, Lanzhou 730000, China, Email:
zqxu
lzu.edu.cn, wangruilzu.edu.cn
C. Wang, Y. Lei, M. Guo, Q. Shang, H. Liu, Z. Xu, R. Wang, Org. Lett., 2017, 19, 6412-6415.
DOI: 10.1021/acs.orglett.7b03289
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Abstract
An UV light-induced, copper-catalyzed decarboxylative coupling of α,β-unsaturated acids with 1°, 2°, and 3° alkyl iodides provides alkenes in good yields and high stereoselectivities.
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proposed mechanism
Key Words
ID: J54-Y2017
