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Carbonyl Iron Powder: A Reagent for Nitro Group Reductions under Aqueous Micellar Catalysis Conditions

Nicholas R. Lee, Agata A. Bikovtseva, Margery Cortes-Clerget, Fabrice Gallou and Bruce H. Lipshutz*

*Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States, Email:

N. R. Lee, A. A. Bikovtseva, M. Cortes-Clerget, F. Gallou, B. H. Lipshutz, Org. Lett., 2017, 19, 6518-6521.

DOI: 10.1021/acs.orglett.7b03216 (free Supporting Information)


The very inexpensive carbonyl iron powder (CIP), a highly active commercial grade of iron powder, enables an especially mild, safe, efficient, and environmentally responsible reduction of aromatic and heteroaromatic nitro groups in water. These reductions are conducted in a recyclable aqueous reaction medium in the presence of nanomicelles composed of TPGS-750-M.

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Key Words

Reduction of Nitro Compounds, Iron, Green Chemistry

ID: J54-Y2017