Iron Catalyzed Hydroboration of Aldehydes and Ketones

Sem Raj Tamang and Michael Findlater*

*Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409, United States, Email: Michael.Findlaterttu.edu

S. R. Tamang, M. Findlater, J. Org. Chem., 2017, 82, 12857-12862.

DOI: 10.1021/acs.joc.7b02020

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Abstract

An operationally convenient hydroboration of aldehydes and ketones employing Fe(acac)₃ as precatalyst proceeded efficiently at room temperature to yield, after work up, 1° and 2° alcohols. A σ-bond metathesis mechanism with an Fe-H intermediate as key reactive species is postulated.

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proposed mechanism

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Key Words

reduction of carbonyl compounds, pinacolborane

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ID: J42-Y2017