Mn(OAc)₃-Promoted Oxidative C_sp³-P Bond Formation through C_sp²-C_sp² and P-H Bond Cleavage: Access to β-Ketophosphonates

Pan Zhou, Biao Hu, Lingdan Li, Kairui Rao, Jiao Yang and Fuchao Yu*

*Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China, Email: yufuchao05126.com

P. Zhou, B. Hu, L. Li, K. Rao, J. Yang, F. Yu, J. Org. Chem., 2017, 82, 13268-13276.

DOI: 10.1021/acs.joc.7b02391

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Abstract

A Mn(OAc)₃-promoted oxidative phosphonylation of N,N-dimethylenaminones with H-phosphonates provides functionalized β-ketophosphonates in very good yields under mild reaction conditions. This method offers operational simplicity, broad substrate scope, and large-scale preparation.

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proposed mechanism

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Key Words

phosphonates, manganese compounds

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ID: J42-Y2017