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Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines

Ricardo Labes, Davir González-Calderón, Claudio Battilocchio, Carlos Mateos*, Graham R. Cumming, Oscar de Frutos, Juan A. Rincón, Steven V. Ley*

*Centro de Investigación Lilly S.A., Avda. de la Industria 30, Alcobendas-Madrid 28108, Spain; University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK, Email: c.mateoslilly.com, svl1000cam.ac.uk

R. Labes, D. González-Calderón, C. Battilocchio, C. Mateos, G. R. Cumming, O. de Frutos, J. A. Rincón, S. V. Ley, Synlett, 2017, 28, 2855-2858.

DOI: 10.1055/s-0036-1589096 (free Supporting Information)


Abstract

A continuous flow method for the selective reduction of aromatic nitriles to the corresponding primary amines is based on a ruthenium-catalysed transfer-hydrogenation process with isopropanol as both solvent and reducing agent.

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Key Words

reduction of nitriles, transfer hydrogenation, ruthenium, primary amine, isopropanol, flow chemistry


ID: J60-Y2017