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Copper-Catalyzed C-S Cross-Coupling Reaction: S-Arylation of Arylthioureas

Hui Zhu, Xing Liu, Cai-Zhu Chang, Zhi-Bing Dong*

*School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, P. R. of China, Email: dzb04982wit.edu.cn

H. Zhu, X. Liu, C.-Z. Chang, Z.-B. Dong, Synthesis, 2017, 49, 5211-5216.

DOI: 10.1055/s-0036-1590879 (free Supporting Information)


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Abstract

A simple and efficient copper-catalyzed S-arylation of aryl­thioureas provides aryl-isothioureas. This ligand-free method offers good yield, short reaction time, and broad substrate scope.

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Key Words

copper, S-arylation, catalysis, thioureas, isothioureas


ID: J66-Y2017