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Gold-Catalyzed Synthesis of Substituted 3-Trifluoromethylpyrroles from Mesylated Amino Trifluoromethylpropargylic Alcohols

Benjamin Guieu, Myriam Le Roch, Michèle David and Nicolas Gouault*

*Equipe CORINT, UMR 6226, Université de Rennes 1, 2 avenue du Pr. Léon Bernard, 35043 Rennes Cedex, France, Email: nicolas.gouaultuniv-rennes1.fr

B. Guieu, M. Le Roch, M. David, N. Gouault, J. Org. Chem., 2017, 82, 13708-13713.

DOI: 10.1021/acs.joc.7b02567 (free Supporting Information)


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Abstract

A series of substituted 3-trifluoromethylpyrroles was obtained in good yield from trifluoromethylamino-ynol derivatives via mesylation and a gold-catalyzed cyclization under mild conditions.

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proposed mechanism



Key Words

pyrroles


ID: J42-Y2017