One-Pot Synthesis of Polysubstituted Imidazoles via Sequential Staudinger/aza-Wittig/Ag(I)-Catalyzed Cyclization/Isomerization
Jun Xiong, Xiao Wei, Zi-Ming Liu and Ming-Wu Ding*
*Key Laboratory of Pesticide & Chemical Biology of Ministry
of Education, Central China Normal University, Wuhan 430079, P. R. China, Email:
mwding
mail.ccnu.edu.cn
J. Xiong, X. Wei, Z.-M. Liu, M.-W. Ding, J. Org. Chem., 2017, 82, 13735-13739.
DOI: 10.1021/acs.joc.7b02606
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Abstract
A sequential Staudinger/aza-Wittig/Ag(I)-catalyzed cyclization/isomerization reaction of easily accessible propargylazide derivatives with triphenylphosphine, isocyanates, and amines provided fully substituted imidazoles in good overall yields.
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proposed mechanism
Key Words
imidazoles, Staudinger reaction
ID: J42-Y2017
