Oxidative Dehomologation of Aldehydes with Oxygen as a Terminal Oxidant
Sergei A. Shipilovskikh, Aleksandr E. Rubtsov* and Andrei V. Malkov*
*Department of Chemistry, Perm State University, Bukireva 15, Perm 614990, Russia; Department of Chemistry, Loughborough University, Loughborough, Leics LE11 3TU, U.K., Email: Rubtsovpsu.ru, A.Malkovlboro.ac.uk
S. A. Shipilovskikh, A. E. Rubtsov, A. V Malkov, Org. Lett., 2017, 19, 6760-6762.
DOI: 10.1021/acs.orglett.7b03512 (free Supporting Information)
see article for more reactions
The use of alkali metal hydrides as reagents enables a mild, efficient protocol for the aerobic oxidative cleavage of C-C bonds in aldehydes. The method is applicable to a broad substrate range.
see article for more examples