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Oxidative Dehomologation of Aldehydes with Oxygen as a Terminal Oxidant

Sergei A. Shipilovskikh, Aleksandr E. Rubtsov* and Andrei V. Malkov*

*Department of Chemistry, Perm State University, Bukireva 15, Perm 614990, Russia; Department of Chemistry, Loughborough University, Loughborough, Leics LE11 3TU, U.K., Email: Rubtsovpsu.ru, A.Malkovlboro.ac.uk

S. A. Shipilovskikh, A. E. Rubtsov, A. V Malkov, Org. Lett., 2017, 19, 6760-6762.

DOI: 10.1021/acs.orglett.7b03512 (free Supporting Information)


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Abstract

The use of alkali metal hydrides as reagents enables a mild, efficient protocol for the aerobic oxidative cleavage of C-C bonds in aldehydes. The method is applicable to a broad substrate range.


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Key Words

Ketones, Oxygen


ID: J54-Y2017