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Base-Promoted Synthesis of O-Aryl/Alkyl N,N-Dimethylthiocarbamates Starting from Inexpensive and Environmentally Benign Disulfide

Zhi-Bing Dong*, Ming Wang, Hui Zhu, Xing Liu, Cai-Zhu Chang

*School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, P. R. of China, Email:

Z.-B. Dong, M. Wang, H. Zhu, X. Liu, C.-Z. Chang, Synthesis, 2017, 49, 5258-5262.

DOI: 10.1055/s-0036-1588545 (free Supporting Information)

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The reaction of inexpensive, stable, and environmentally benign tetramethylthiuram disulfide (TMTD) with substituted phenols or alkyl alcohols in the presence of NaH provides N,N-dimethylthiocarbamates in good yields. This green and facile preparation avoids the use of toxic and corrosive N,N-dialkylthiocarbamoyl chlorides.

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Key Words

thiocarbamates, disulfide, phenols, sodium hydride

ID: J66-Y2017