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Rapidly Activating Pd-Precatalyst for Suzuki-Miyaura and Buchwald-Hartwig Couplings of Aryl Esters

Amira H. Dardir, Patrick R. Melvin, Ryan. M. Davis, Nilay Hazari* and Megan Mohadjer Beromi

*The Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520, United States, Email: nilay.hazariyale.edu

A. H. Dardir, P. R. Melvin, R. M. Davis, N. Hazari, M. M. Beromi, J. Org. Chem., 2018, 83, 469-477.

DOI: 10.1021/acs.joc.7b02588 (free Supporting Information)


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Abstract

A recently discovered precatalyst enables Pd-catalyzed Suzuki-Miyaura and Buchwald-Hartwig reactions involving cleavage of a C(acyl)-O bond of aryl esters as electrophiles under mild conditions. The Pd(II) precatalyst is highly active due to its fast reduction to a Pd(0) active species.


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Key Words

Buchwald-Hartwig Coupling, Amides


ID: J42-Y2018