Synthesis of Internal Alkynes through an Effective Tandem Elimination-Hydrodebromination-Cross-Coupling of gem-Dibromoalkenes with Halobenzenes
Yuan Ji, Ning Zhong, Zinan Kang, Guobing Yan*, Ming Zhao*
*Department of Chemistry, Lishui University, Lishui 323000; School of Chemical Engineering, China University of Mining and Technology, Xuzhou 221116, P. R. of China, Email: gbyanlsu.edu.cn, ming815zhaoaliyun.com
Y. Ji, N. Zhong, Z. Kang, G. Yan, M. Zhao, Synlett, 2018, 29, 209-214.
DOI: 10.1055/s-0036-1590907 (free Supporting Information)
A palladium-catalyzed C-C cross-coupling reaction of gem-dibromoalkenes and halobenzenes provides terminal alkynes in one pot through a tandem elimination-hydrodebromination process. This convenient reaction proceeded under copper-free Sonogashira coupling reaction conditions in good to excellent yields.
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