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A Robust One-Step Approach to Ynamides

Yongliang Tu, Xianzhu Zeng, Hui Wang and Junfeng Zhao*

*Key Laboratory of Chemical Biology of Jiangxi Province, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, Jiangxi, P. R. China, Email:

Y. Tu, X. Zeng, H. Wang, J. Zhao, Org. Lett., 2018, 20, 280-283.

DOI: 10.1021/acs.orglett.7b03665

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A robust one-step synthesis of ynamides from vinyl dichlorides and electron deficient amides as cheap and easily available starting materials proceeds under mild reaction conditions in open air In the absence of a transition-metal catalyst. This strategy is not only suitable for the synthesis of both terminal and internal ynamides but also amenable for large-scale preparation.

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proposed mechanism

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ID: J54-Y2018