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One-Pot Assembly towards ω-Substituted Arylbiurets from Aromatic Amines, Potassium Cyanate, and Glacial Acetic Acid

Xiangting Min, Jianhui Liu*, Yawen Dong, Mustafa Hussain

*State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, P. R. of China, Email:

X. Min, J. Liu, Y. Dong, M. Hussain, Synthesis, 2018, 50, 341-348.

DOI: 10.1055/s-0036-1590934 (free Supporting Information)


A simple and highly efficient synthesis of ω-substituted arylbiurets in a one-pot reaction from readily available starting materials offers an easy work-up procedure and good yields. ω-Substituted arylbiurets can be selectively prepared with an excess of potassium cyanate (KOCN), while an excess of glacial acetic acid (AcOH) switches the reaction towards the formation of N-monosubstituted urea.

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Key Words

ω-substituted biurets, N-monosubstituted ureas, urea derivatives, potassium cyanate, dicyanic acid, selective reactions

ID: J66-Y2018