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Photoredox-Catalyzed Decarboxylative Alkylation of Silyl Enol Ethers To Synthesize Functionalized Aryl Alkyl Ketones

Weiguang Kong, Changjiang Yu, Hejun An and Qiuling Song*

*Institute of Next Generation Matter Transformation, College of Chemical Engineering & College of Material Sciences Engineering at Huaqiao University, 668 Jimei Boulevard, Xiamen, Fujian 361021, P. R. China, Email: qsonghqu.edu.cn

W. Kong, C. Yu, H. An, Q. Song, Org. Lett., 2018, 20, 349-352.

DOI: 10.1021/acs.orglett.7b03587 (free Supporting Information)



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Abstract

A photoredox-catalyzed decarboxylative alkylation of silyl enol ethers provides diverse functionalized aryl alkyl ketones in good yields using N-(acyloxy)phthalimides as an easy access alkyl radical source under mild and operationally simple conditions.


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proposed mechanism



Key Words

alkylation, photochemistry


ID: J54-Y2018