Organic Chemistry Portal



Elemental Sulfur-Mediated Decarboxylative Redox Cyclization Reaction: Copper-Catalyzed Synthesis of 2-Substituted Benzothiazoles

Xin Wang, Xiaotong Li, Renhe Hu, Zhao Yang, Ren Gu, Sai Ding, Pengyi Li, Shiqing Han*

*College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, P. R. of China, Email:

X. Wang, X. Li, R. Hu, Z. Yang, R. Gu, S. Ding, P. Li, S. Han, Synlett, 2018, 29, 219-224.

DOI: 10.1055/s-0036-1589112


A synthesis of 2-substituted benzothiazoles in good yields from o-iodoanilines, arylacetic acids, and elemental sulfur is catalyzed by cheap copper metal. This S8-mediated directed decarboxylative redox-cyclization strategy is operationally simple, ligand-free, and compatible with a wide range of functional groups.

see article for more examples

Key Words

benzothiazoles, decarboxylative cyclization, o-iodoanilines, arylacetic acids, elemental sulfur, multicomponent reactions

ID: J60-Y2018