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Photoredox-Induced Radical Relay toward Functionalized β-Amino Alcohol Derivatives

Xiao-De An, Yan-Yan Jiao, Hao Zhang, Yuxiang Gao and Shouyun Yu*

*Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China, Email: yushouyunnju.edu.cn

X.-D. An, Y.-Y. Jiao, H. Zhang, Y. Gao, S. Yu, Org. Lett., 2018, 20, 401-404.

DOI: 10.1021/acs.orglett.7b03693 (free Supporting Information)



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Abstract

Photoredox-catalyzed and nitrogen-centered radical-triggered cascade reactions of styrenes (or phenylacetylenes), enol derivatives, and O-acyl hydroxylamines in DMSO provide functionalized β-amino alcohols. Structurally diverse reaction components, including complex molecular scaffolds can be converted.

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proposed mechanism



Key Words

allylic alcohols, β-amino alcohols, photochemistry, multicomponent reactions


ID: J54-Y2018