Bu₄NI-Catalyzed Dehydrogenative Coupling of Diaryl Phosphinic Acids with C(sp³)-H Bonds of Arenes

Biquan Xiong* , Gang Wang, Congshan Zhou, Yu Liu, Panliang Zhang and Kewen Tang*

*Department of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414006, P. R. China, Email: xiongbiquan126.com, tangkewensina.com

B. Xiong, G. Wang, C. Zhou, Y. Liu, P. Zhang, K. Tang, J. Org. Chem., 2018, 83, 993-999.

DOI: 10.1021/acs.joc.7b02422

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Abstract

An efficient phosphorylation of C(sp³)-H bonds of readily available methyl arenes with diaryl phosphinic acids proceeds efficiently under transition-metal-free reaction conditions via Bu₄NI-catalyzed dehydrogenative coupling to provide valuable organophosphorus compounds.

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proposed mechanism

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Key Words

Benzyl Alcohol Derivatives, TBHP, Phosphinates, Phosphorylation, Dehydrogenative coupling, Diaryl phosphinic acids, Methyl arenes

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ID: J42-Y2018