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Iron-Catalyzed Aerobic Oxidation and Annulation Reaction of Pyridine and α-Substituted Allenoate toward Functionalized Indolizine

Tao Jin, Zhongzhong Tang, Jie Hu, Hongdong Yuan, Yaoyao Chen, Chunju Li, Xueshun Jia* and Jian Li*

*Department of Chemistry, Shanghai University, 99 Shangda Road, Shanghai 200444, P. R. China, Email: xsjiamail.shu.edu.cn, lijianshu.edu.cn

T. Jin, Z. Tang, J. Hu, H. Yuan, Y. Chen, C. Li, X. Jia, J. Li, Org. Lett., 2018, 20, 413-416.

DOI: 10.1021/acs.orglett.7b03696 (free Supporting Information)


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Abstract

An iron-catalyzed synthesis of functionalized indolizines from pyridine and α-substituted allenoate incorporates an annulation followed by an aerobic oxidation.


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proposed mechanism



Key Words

indolizines, oxygen


ID: J54-Y2018