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Copper-Catalyzed Diamination of Alkenes of Unsaturated Ketohydrazones with Amines

Manman Chen, Li-Jing Wang*, Pei-Xing Ren, Xiao-Ying Hou, Zhang Fang, Meng-Nan Han and Wei Li*

*College of Chemistry & Environmental Science, HeBei University, 180 Wusi Donglu, Baoding 071002, P. R. China, Email:,

M. Chen, L.-J. Wang, P.-X. Ren, X.-Y. Hou, Z. Fang, M.-N. Han, W. Li, Org. Lett., 2018, 20, 510-513.

DOI: 10.1021/acs.orglett.7b03401 (free Supporting Information)

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A convenient copper-catalyzed intra-/intermolecular diamination of β,γ-unsaturated hydrazones with simple amines enables an efficient access to various nitrogen-containing pyrazolines under mild reaction conditions.

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proposed mechanism

Key Words


ID: J54-Y2018