Chelate-Assisted Ring-Closing Metathesis: A Strategy for Accelerating Macrocyclization at Ambient Temperatures
Carolyn S. Higman, Daniel L. Nascimento, Benjamin J. Ireland, Stephan Audörsch, Gwendolyn A. Bailey, Robert McDonald and Deryn E. Fogg*
*Center for Catalysis Research & Innovation, and Department
of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Canada K1N
6N5, Email: dfogg
uottawa.ca
C. S. Higman, D. L. Nascimento, B. J. Ireland, S. Audörsch, G. A. Bailey, R. McDonald, D. E. Fogg, J. Am. Chem. Soc., 2018, 140, 1604-1607.
DOI: 10.1021/jacs.7b13257
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Abstract
Incorporation of a hemilabile o-dianiline (ODA) chelate into Ru complexes of N-heterocyclic carbenes accelerates ring-closing metathesis macrocyclization, particularly for dienes bearing polar sites capable of H-bonding. The ligand may also inhibit catalyst decomposition during metathesis.
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Key Words
ID: J48-Y2018
