Direct Synthesis of Quinolines via Co(III)-Catalyzed and DMSO-Involved C-H Activation/Cyclization of Anilines with Alkynes

Xuefeng Xu, Yurong Yang, Xu Zhang* and Wei Yi*

*Nanyang Normal University, Nanyang 473061; Guangzhou Medical University, Guangzhou, Guangdong 511436, China, Email: yiweigzhmu.edu.cn, zhangxuedu126.com

X. Xu, Y. Yang, X. Zhang, W. Yi, Org. Lett., 2018, 20, 566-569.

DOI: 10.1021/acs.orglett.7b03673

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Abstract

A highly efficient and regioselective Co(III)-catalyzed C-H activation/cyclization of simple, cheap, and easily available anilines with alkynes enables a direct synthesis of a broad range of privileged quinolines. In this reaction, DMSO serves both as the solvent and a C₁ building block.

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proposed mechanism

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Key Words

Quinolines, Potassium Peroxydisulfate, Multicomponent Reactions

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ID: J54-Y2018