Copper-Catalyzed Synthesis of Aryl Thioamides from Aryl Aldehydes and Tetramethylthiuram Disulfide
Meng-Tian Zeng, Min Wang, Han-Ying Peng, Yu Cheng, Zhi-Bing Dong*
*School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, P. R. of China, Email: dzb04982wit.edu.cn
M.-T. Zeng, M. Wang, H.-Y. Peng, Y. Cheng, Z.-B. Dong, Synthesis, 2018, 50, 644-650.
DOI: 10.1055/s-0036-1590936 (free Supporting Information)
A convenient method for the synthesis of aryl thioamides from aryl aldehydes and tetramethylthiuram disulfide (TMTD) in the presence of CuI and di-tert-butyl peroxide (DTBP) avoids the use of a sulfurating reagent. The protocol offers broad substrate scope, very good yields, operability and uses commercially available and inexpensive raw materials.
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