Copper-Catalyzed Synthesis of Aryl Thioamides from Aryl Aldehydes and Tetramethylthiuram Disulfide
Meng-Tian Zeng, Min Wang, Han-Ying Peng, Yu Cheng, Zhi-Bing Dong*
*School of Chemistry and Environmental Engineering, Wuhan
Institute of Technology, Wuhan 430205, P. R. of China, Email: dzb04982
wit.edu.cn
M.-T. Zeng, M. Wang, H.-Y. Peng, Y. Cheng, Z.-B. Dong, Synthesis, 2018, 50, 644-650.
DOI: 10.1055/s-0036-1590936
Abstract
A convenient method for the synthesis of aryl thioamides from aryl aldehydes and tetramethylthiuram disulfide (TMTD) in the presence of CuI and di-tert-butyl peroxide (DTBP) avoids the use of a sulfurating reagent. The protocol offers broad substrate scope, very good yields, operability and uses commercially available and inexpensive raw materials.
see article for more examples
Key Words
thioamides (thionation, amination), benzaldehydes, tetramethylthiuram disulfide, copper, di-tert-butyl peroxide
ID: J66-Y2018
