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Copper-Catalyzed Synthesis of Aryl Thioamides from Aryl Aldehydes and Tetramethylthiuram Disulfide

Meng-Tian Zeng, Min Wang, Han-Ying Peng, Yu Cheng, Zhi-Bing Dong*

*School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, P. R. of China, Email:

M.-T. Zeng, M. Wang, H.-Y. Peng, Y. Cheng, Z.-B. Dong, Synthesis, 2018, 50, 644-650.

DOI: 10.1055/s-0036-1590936


A convenient method for the synthesis of aryl thioamides from aryl aldehydes and tetramethylthiuram disulfide (TMTD) in the presence of CuI and di-tert-butyl peroxide (DTBP) avoids the use of a sulfurating reagent. The protocol offers broad substrate scope, very good yields, operability and uses commercially available and inexpensive raw materials.

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Key Words

thioamides (thionation, amination), benzaldehydes, tetramethylthiuram disulfide, copper, di-tert-butyl peroxide

ID: J66-Y2018