Ir/Cu Dual Catalysis: Enantio- and Diastereodivergent Access to α,α-Disubstituted α-Amino Acids Bearing Vicinal Stereocenters
Xiaohong Huo, Jiacheng Zhang, Jingke Fu, Rui He and Wanbin Zhang*
*School of Chemistry and Chemical Engineering and School of
Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P.
R. China, Email: wanbin
sjtu.edu.cn
X. Huo, J. Zhang, J. Fu, R. He, W. Zhang, J. Am. Chem. Soc., 2018, 140, 2080-2084.
DOI: 10.1021/jacs.8b00187
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Abstract
A Ir/Cu-catalyzed α-allylation of readily available imine esters enables a fully stereodivergent synthesis of a range of α,α-disubstituted α-amino acids. Importantly, the two chiral catalysts allow for full control over the configuration of the stereocenters, affording all stereoisomers of the desired products.
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Key Words
ID: J48-Y2018
