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Nickel-Catalyzed Domino Heck Cyclization/Suzuki Coupling for the Synthesis of 3,3-Disubstituted Oxindoles

Yuxiu Li, Kuai Wang, Yuanyuan Ping, Yifan Wang and Wangqing Kong*

*The Institute for Advanced Studies, Wuhan University, 299 Bayi Road, Wuchang District, Wuhan, Hubei 430072, P. R. China, Email: wqkongwhu.edu.cn

Y. Li, K. Wang, Y. Ping, Y. Wang, W. Kong, Org. Lett., 2018, 20, 921-924.

DOI: 10.1021/acs.orglett.7b03713 (free Supporting Information)



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Abstract

A nickel-catalyzed domino Heck cyclization/Suzuki coupling reaction enables the synthesis of 3,3-disubstituted oxindoles bearing quaternary all-carbon centers. A wide range of electrophiles, such as aryl iodides, bromides, triflates, chlorides, and cheap aryl esters can be employed. This practical and sustainable reaction offers good yields and broad scope.

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Key Words

oxindoles


ID: J54-Y2018