Organic Chemistry Portal

Abstracts

Search:

Nickel-Catalyzed Domino Heck Cyclization/Suzuki Coupling for the Synthesis of 3,3-Disubstituted Oxindoles

Yuxiu Li, Kuai Wang, Yuanyuan Ping, Yifan Wang and Wangqing Kong*

*The Institute for Advanced Studies, Wuhan University, 299 Bayi Road, Wuchang District, Wuhan, Hubei 430072, P. R. China, Email: wqkongwhu.edu.cn

Y. Li, K. Wang, Y. Ping, Y. Wang, W. Kong, Org. Lett., 2018, 20, 921-924.

DOI: 10.1021/acs.orglett.7b03713



see article for more reactions

Abstract

A nickel-catalyzed domino Heck cyclization/Suzuki coupling reaction enables the synthesis of 3,3-disubstituted oxindoles bearing quaternary all-carbon centers. A wide range of electrophiles, such as aryl iodides, bromides, triflates, chlorides, and cheap aryl esters can be employed. This practical and sustainable reaction offers good yields and broad scope.

see article for more examples



Key Words

oxindoles


ID: J54-Y2018