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Rhodium-Catalyzed Enantioselective Decarboxylative Alkynylation of Allenes with Arylpropiolic Acids

Christian P. Grugel and Bernhard Breit*

*Institut für Organische Chemie, Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104 Freiburg im Breisgau, Germany, Email:

C. P. Grugel, B. Breit, Org. Lett., 2018, 20, 1066-1069.

DOI: 10.1021/acs.orglett.7b04035

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A rhodium-catalyzed chemo-, regio-, and enantioselective intermolecular decarboxylative alkynylation of terminal allenes with arylpropiolic acids provides branched allylic 1,4-enynes under mild conditions. This reaction offers a broad functional group compatibility.

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proposed mechanism

Key Words


ID: J54-Y2018