Rhodium-Catalyzed Enantioselective Decarboxylative Alkynylation of Allenes with Arylpropiolic Acids
Christian P. Grugel and Bernhard Breit*
*Institut für Organische Chemie, Albert-Ludwigs-Universität
Freiburg, Albertstrasse 21, 79104 Freiburg im Breisgau, Germany, Email:
bernhard.breit
chemie.uni-freiburg.de
C. P. Grugel, B. Breit, Org. Lett., 2018, 20, 1066-1069.
DOI: 10.1021/acs.orglett.7b04035
see article for more reactions
Abstract
A rhodium-catalyzed chemo-, regio-, and enantioselective intermolecular decarboxylative alkynylation of terminal allenes with arylpropiolic acids provides branched allylic 1,4-enynes under mild conditions. This reaction offers a broad functional group compatibility.
see article for more examples
proposed mechanism
Key Words
ID: J54-Y2018
