Transfer Hydrogenation of Aldehydes and Ketones with Isopropanol under Neutral Conditions Catalyzed by a Metal-Ligand Bifunctional Catalyst [Cp*Ir(2,2′-bpyO)(H₂O)]

Rongzhou Wang, Yawen Tang, Meng Xu, Chong Meng and Feng Li*

*School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, People's Republic of China, Email: fenglinjust.edu.cn

R. Wang, Y. Tang, M. Xu, C. Meng, F. Li, J. Org. Chem., 2018, 83, 2274-2281.

DOI: 10.1021/acs.joc.7b03174

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Abstract

[Cp*Ir(2,2′-bpyO)(H₂O)] is a highly efficient and general catalyst for transfer hydrogenation of carbonyl compounds and chemoselective transfer hydrogenation of unsaturated aldehydes with isopropanol under neutral conditions. The reaction tolerates deducible groups such as nitro, cyano, ester, and halide.

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proposed mechanism

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Transfer Hydrogenation of Ketones and Imines with Methanol under Base-Free Conditions Catalyzed by an Anionic Metal-Ligand Bifunctional Iridium Catalyst

R. Wang, X. Han, J. Xu, P. Liu, F. Li, J. Org. Chem., 2020, 85, 2242-2249.

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Key Words

reduction of carbonyl compounds, reduction of α,β-unsaturated compounds, isopropanol

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ID: J42-Y2018