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Synthesis of Polysubstituted Quinolines from α-2-Aminoaryl Alcohols Via Nickel-Catalyzed Dehydrogenative Coupling

Sanju Das, Debabrata Maiti and Suman De Sarkar*

*Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, West Bengal, India, Email: sdsiiserkol.ac.in

S. Das, D. Maiti, S. D. Sarkar, J. Org. Chem., 2018, 83, 2309-2316.

DOI: 10.1021/acs.joc.7b03198 (free Supporting Information)


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Abstract

A nickel-catalyzed sequential dehydrogenation and condensation process enables a sustainable synthesis of a wide range of polysubstituted quinolines from α-2-aminoaryl alcohols. This strategy allows the use of both primary as well as secondary α-2-aminoaryl alcohols in combination with either ketones or secondary alcohols for desired product formation.

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proposed mechanism



Key Words

quinolines


ID: J42-Y2018