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Synthesis of 5-(Trifluoromethyl)pyrazolines by Formal [4 + 1]-Annulation of Fluorinated Sulfur Ylides and Azoalkenes

Zhiyong Wang, Yanzhou Yang, Fang Gao, Zhiyong Wang*, Qian Luo and Ling Fang*

*Chongqing University, Chongqing 401331; Chongqing Technology and Business University, Chongqing 400067, China, Email:,

Z. Wang, Y. Yang, F. Gao, Z. Wang, Q. Luo, L. Fang, Org. Lett., 2018, 20, 934-937.

DOI: 10.1021/acs.orglett.7b03811 (free Supporting Information)

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In situ formed 1,2-diaza-1,3-dienes were used in formal [4 + 1]-annulation reactions with fluorinated sulfur ylides to provide 5-(trifluoromethyl)pyrazolines in good yields.

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Key Words


ID: J54-Y2018