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Selective Construction of 2-Substituted Benzothiazoles from o-Iodoaniline Derivatives S8 and N-Tosylhydrazones

Yubing Huang, Peiqi Zhou, Wanqing Wu* and Huanfeng Jiang*

*School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P. R. China, Email:,

Y. Huang, P. Zhou, W. Wu, H. Jiang, J. Org. Chem., 2018, 83, 2460-2466.

DOI: 10.1021/acs.joc.7b03118

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A copper-promoted [3 + 1 + 1]-type cyclization reaction enables a selective construction of 2-aryl or 2-benzyl substituted benzothiazoles from o-iodoaniline derivatives, S8, and N-tosylhydrazones depending on the reaction system.

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Key Words

benzothiazoles, multicomponent reactions

ID: J42-Y2018