A Selective and Functional Group-Tolerant Ruthenium-Catalyzed Olefin Metathesis/Transfer Hydrogenation Tandem Sequence Using Formic Acid as Hydrogen Source
Grzegorz K. Zieliński, Jarosława Majtczak, Maciej Gutowski and Karol Grela*
*Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, Warsaw, Poland, Email: karol.grelagmail.com
G. K. Zieliński, J. Majtczak, M. Gutowski, K. Grela, J. Org. Chem., 2018, 83, 2542-2553.
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A ruthenium-catalyzed transfer hydrogenation of olefins utilizing formic acid as a hydrogen donor provides a remarkable and chemoselective synthetic tool for the reduction of functionalized alkenes under mild reaction conditions. An olefin metathesis/transfer hydrogenation sequence under tandem catalysis conditions enables an attractive C(sp3)-C(sp3) bond formation.
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cyclopentanes, ring closing metathesis, formic acid